[Analysis of the role of presynaptic adrenoreceptors in adrenergic synaptic transmission]

A mathematical model quantitatively describing the value of secreted mediator per each successive impulse in the series of presynaptic impulses is presented. The model is plotted with the account taken of the role of presynaptic adrenoreceptors regulating noradrenaline secretion. It has been shown that a decrease observed in neurophysiological experiments and further stabilization of postsynaptic responses in the series of presynaptic impulses of given frequency are not connected with a decreased content of noradrenaline in nerve endings, but may be connected with the work of presynaptic alpha and beta adrenoreceptors.