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Cerebral cladosporiosis--a neuropathological and microbiological study
Abstract:
Cerebral cladosporiosis is a rare mycotic infection of the brain. So far only 21 culture-proven cases of cerebral cladosporiosis have been listed in literature (FETTER et al. 1967, FETTER and KLINTWORTH, 1978). In view of the rarity of this mycotic infection and its clinical importance we report two cases of culture-proven cerebral cladosporiosis. They presented as meningoencephalitis with extensive areas of haemorrhagic infarctions of frontoparietal lobes. Both patients were middle-aged farmers from Karnataka State, South India. The clinical, neuropathological and mycological features are presented.
Insights
Cerebral cladosporiosis, a rare brain infection, is detailed in two new cases. These cases highlight the meningoencephalitis and brain infarction associated with this fungal disease.
Area of Science:
- Neurology
- Mycology
- Infectious Diseases
Background:
- Cerebral cladosporiosis is an exceptionally rare fungal infection affecting the brain.
- Only 21 cases have been documented in medical literature prior to this report.
- The rarity underscores the need for increased awareness and reporting.
Observation:
- Two new cases of culture-proven cerebral cladosporiosis are presented.
- Patients presented with meningoencephalitis, a severe inflammation of the brain and meninges.
- Extensive hemorrhagic infarctions in the frontoparietal lobes were observed.
Findings:
- The study details the clinical, neuropathological, and mycological aspects of these two cases.
- Both affected individuals were middle-aged farmers from South India.
- The findings contribute to understanding the presentation of this rare mycosis.
Implications:
- Increased recognition of cerebral cladosporiosis is crucial for timely diagnosis and treatment.
- Further research into this rare fungal infection is warranted.
- This report expands the known clinical spectrum and geographical distribution of cerebral cladosporiosis.