[Effect of GABA-ergic substances on the elaboration of conditioned reflexes in rats under negative reinforcement]

Experiments on female rats have shown that gabalid (100 and 200 mg/kg) does not essentially change the formation of the conditioned reflexes in intact animals and in those with an involved caudate nucleus whereas cainic acid injected intraperitoneally (15 mg/kg) and applied to the caudate nucleus deteriorates and when given in a dose of 5 mg/kg improves the formation of the conditioned reflexes. Baclofen (10 mg/kg) inhibits the conditioned reflexes in both intact animals and in those with an involved caudate nucleus, whereas in a dose of 1 mg/kg the drug improves it in intact animals and inhibits it in animals with impaired function of the caudate nucleus. The importance of the GABA-ergic system of the caudate nucleus for the action of GABA-ergic agents on the conditioned reflexes in rats is discussed.