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Tumor seeding associated with bone marrow aspiration and biopsy
Archives of Internal Medicine
|January 1, 1984
Summary
Tumor seeding from small-cell lung carcinoma occurred after bone marrow aspiration and biopsy. This rare complication highlights a potential risk associated with invasive procedures in cancer patients.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Small-cell lung carcinoma (SCLC) staging often involves bone marrow aspiration and biopsy.
- Autologous bone marrow infusion is a therapeutic option for certain cancers.
Observation:
- A patient with SCLC developed a subcutaneous lesion 14 months post-procedure.
- The lesion was located over the posterior iliac crest.
Findings:
- Biopsy of the subcutaneous lesion confirmed recurrent small-cell carcinoma.
- This represents a potential case of tumor seeding via bone marrow aspiration/biopsy.
Implications:
- Highlights a rare but serious complication of bone marrow procedures in oncology.
- Suggests careful consideration of iatrogenic tumor spread in patients with SCLC.
- May inform future protocols for invasive procedures in cancer staging and treatment.