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Increased vascular beta2-adrenoceptor responsiveness in autonomic dysfunction.

D Robertson, A S Hollister, E L Carey

    Journal of the American College of Cardiology
    |March 1, 1984
    PubMed
    Summary
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    Patients with autonomic dysfunction exhibit significantly increased sensitivity to sympathomimetic amines like isoproterenol and phenylephrine. Caution is advised when using beta-adrenoceptor agonists to prevent dangerous hypotension.

    Area of Science:

    • Pharmacology
    • Autonomic Nervous System Physiology

    Background:

    • Sympathomimetic amines are crucial in managing cardiovascular conditions.
    • Autonomic dysfunction significantly impacts the body's response to various stimuli.

    Purpose of the Study:

    • To assess the responsiveness of patients with severe autonomic dysfunction to sympathomimetic amines.
    • To compare these responses with age-matched healthy controls.

    Main Methods:

    • Assessed vasopressor, vasodepressor, and chronotropic effects of sympathomimetic amines.
    • Compared 12 patients with autonomic dysfunction to 8 age-matched controls.

    Main Results:

    • Patients showed a profound increase in responsiveness to isoproterenol and phenylephrine.

    Related Experiment Videos

  • Responsiveness to isoproterenol's depressor effect was 17-fold higher in patients compared to controls.
  • Chronotropic responsiveness to isoproterenol was 6-fold higher in patients.

    • Conclusions:

    • Individuals with autonomic dysfunction display markedly enhanced sensitivity to the hypotensive effects of beta-adrenoceptor agonists.
    • Caution is essential when administering beta-adrenoceptor agonists to patients with autonomic dysfunction to avoid severe hypotension.