Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model eliciting transient responses.

E B Ekblad, V Licko

    The American Journal of Physiology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a chemical model demonstrating transient responses to sustained stimulation, applicable to biological systems. The model effectively simulates real-world experimental data from toad bladder and frog gastric mucosa.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pulmonary insulin administration using the AERx system: physiological and physicochemical factors influencing insulin effectiveness in healthy fasting subjects.

    Diabetes technology & therapeutics·2001
    Same author

    Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation.

    Toxicological sciences : an official journal of the Society of Toxicology·1999
    Same author

    Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration.

    Toxicologic pathology·1999
    Same author

    Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans.

    Toxicologic pathology·1999
    Same author

    Pharmacokinetics and interspecies scaling of recombinant human factor VIII.

    Toxicology and applied pharmacology·1996
    Same author

    [Infectious endocarditis--new aspects of a well-known disease].

    Vnitrni lekarstvi·1994

    Area of Science:

    • Biochemistry
    • Physiology
    • Mathematical Modeling

    Background:

    • Biological systems often exhibit transient responses to sustained stimuli.
    • Understanding these dynamic responses is crucial for elucidating cellular mechanisms.
    • Existing models may not fully capture the nuances of transient signaling.

    Purpose of the Study:

    • To develop and exemplify a parametrically controlled chemical transformation scheme for modeling transient responses.
    • To analyze the model's applicability using experimental data from biological systems.
    • To investigate the model's response characteristics to sustained stimulation.

    Main Methods:

    • Development of a simple parametrically controlled chemical transformation scheme.
    • Analysis of three experimental examples: toad bladder short-circuit current, frog gastric mucosa histamine secretion, and frog gastric mucosa cAMP dynamics.

    Related Experiment Videos

  • Comparison of model predictions with experimental observations.

    • Main Results:

    • The model successfully exemplifies transient responses to sustained stimulation.
    • Experimental data from toad bladder and frog gastric mucosa align with model predictions.
    • The model's response is primarily driven by changes in stimulator levels, not derivative control.

    Conclusions:

    • A versatile chemical model can effectively simulate transient biological responses.
    • The model provides insights into signaling dynamics in physiological systems.
    • Parametric control offers a viable approach for modeling complex biological responses.