Disorders of the isodendritic core of the brainstem

The dopamine hypothesis of schizophrenia has not lived up to its explanatory potential. Other efforts have been made but have depended heavily on the limbic system in their analysis of the problem. Based on the clinical and basic research that has been conducted so far, the thesis is presented here that the group of schizophrenias is due to disorders of the isodendritic core of the brainstem. The concept of the core is described, and the data that support the contention are presented briefly.