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Rate-sensitive inhibition of ACTH release in depression.

D B Carr, C Wool, R B Lydiard

The American Journal of Psychiatry

|April 1, 1984

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Abnormalities in the hypothalamic-pituitary-adrenal axis are present in depression. Some depressed patients show paradoxical responses to ACTH inhibition, independent of standard tests.

Area of Science:

Neuroendocrinology
Psychiatry

Background:

Rate-sensitive inhibition of adrenocorticotropic hormone (ACTH) release is known to be abnormal in Cushing's disease.
This specific aspect of ACTH regulation has not been previously characterized in patients with depression.

Purpose of the Study:

To investigate rate-sensitive inhibition of ACTH release in patients diagnosed with depression.
To determine if abnormalities in this regulatory mechanism are present in depression and if they are linked to dexamethasone suppression test (DST) results.

Main Methods:

The study assessed the response of ACTH release to specific stimuli in a cohort of 10 patients with depression.
Researchers observed for paradoxical responses, indicating a failure of normal inhibition.

Main Results:

Related Experiment Videos

Two out of the 10 depressed patients exhibited paradoxical responses in ACTH release.
These paradoxical responses suggest an underlying hypothalamic-pituitary-adrenal axis abnormality.

Conclusions:

The findings suggest that hypothalamic-pituitary-adrenal axis abnormalities may be present in a subset of patients with depression.
These abnormalities appear to be independent of the results obtained from the dexamethasone suppression test.