Co-occurrence of multiple sclerosis and glioma--case report and neuropathologic and epidemiologic review

This paper reports on a 54-year-old male in whom multiple sclerosis developed 10 years prior to his death from glioblastoma confirmed at autopsy. A causal relationship is still uncertain despite the 24 cases of concurrent multiple sclerosis and glioma reported since 1938. We discuss the neuropathologic and epidemiologic evidence for and against the hypothesis that multiple sclerosis lesions promote the development of gliomas and conclude that no current reason exists to support the hypothesis.