Localization of angiotensin II binding sites in rat septum by autoradiography

The distribution of septal [125I]angiotensin II (Ang II) binding sites localized by light microscopic autoradiography was compared with the distribution of septal immunoreactive Ang II-containing nerve terminals localized by immunohistochemistry. Within the septum, both the [125I]Ang II binding sites and Ang II-like immunoreactive terminals were restricted to the lateral septal nucleus. The close parallel between the distribution of [125I]Ang II binding sites and immunoreactive Ang II nerve terminals in the lateral septum suggests that central Ang II receptors may be functionally linked to neuronally released Ang II.