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Detection of malignant soft tissue tumors in bone imaging
European Journal of Nuclear Medicine
|January 1, 1984
Summary
Bone scans detected soft tissue neoplasms using bone-seeking phosphonates. Technetium-99m-methylene diphosphonate identified 68 neoplasms across various organs, differing from prior literature findings.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiology
Background:
- Bone-seeking phosphonates are commonly used in bone scintigraphy.
- Soft tissue neoplasms can sometimes accumulate these radiopharmaceuticals.
- Previous studies have reported varying rates of soft tissue neoplasm detection.
Purpose of the Study:
- To evaluate the number and types of soft tissue neoplasms detected using bone-seeking phosphonates.
- To analyze the distribution and characteristics of these detected neoplasms.
- To compare findings with existing literature.
Main Methods:
- Retrospective analysis of 2530 consecutive bone scans.
- Identification and characterization of soft tissue neoplasms accumulating radiotracers.
- Detailed recording of neoplasm location and type.
Main Results:
- Sixty-eight primary or secondary soft tissue neoplasms were identified in 63 patients.
- Technetium-99m-methylene diphosphonate (99mTc-MDP) accumulated in 68 neoplasms, while 99mTc-diphosphonate accumulated in 2.
- Tumor localizations included lung (19), liver (15), kidney (11), and peritoneal cavity (10), among others. One metastasis appeared as a cold focus in the urinary bladder.
Conclusions:
- Bone scintigraphy with bone-seeking phosphonates can detect a significant number of soft tissue neoplasms.
- The observed distribution and detection rates differ from those previously reported in the literature.
- Further investigation is warranted to understand the reasons for these discrepancies.
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