[Greig's syndrome. Neonatal radiologic manifestations]

Area of Science:

• Medical genetics
• Pediatric radiology
• Developmental biology

Background:

• Greig's Syndrome is a rare genetic disorder characterized by craniofacial abnormalities and limb malformations.
• Early diagnosis and understanding of skeletal manifestations are crucial for patient management.

Observation:

• A neonate presented with postaxial hand polydactyly, preaxial foot polydactyly, syndactyly, and craniofacial dysmorphism, consistent with Greig's Syndrome.
• Radiographic examination in the neonatal period revealed specific skeletal anomalies.

Findings:

• New radiological findings in Greig's Syndrome at this age include advanced bone age, distinct iliac bone morphology, and a supernumerary prehallux toe.
• The widespread skeletal anomalies suggest a complex disruption in intrauterine ossification.

Implications:

• These findings expand the understanding of Greig's Syndrome's radiographic spectrum in neonates.
• Further research into intrauterine ossification processes may elucidate the pathogenesis of this syndrome.