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Related Experiment Videos

Peripheral nerve injury by chymopapain injection.

S E Mackinnon, A R Hudson, F Llamas

    Journal of Neurosurgery
    |July 1, 1984
    PubMed
    Summary

    Chymopapain injections for disc disease can cause nerve damage. Intrafascicular injection of chymopapain led to dose-related peripheral nerve fiber damage in rat and primate models.

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    Area of Science:

    • Neuroscience
    • Biochemistry
    • Orthopedic Surgery

    Background:

    • Chemonucleolysis using chymopapain is a clinical treatment for disc disease.
    • Neurosurgical complications have been reported following chemonucleolysis.

    Purpose of the Study:

    • To investigate the potential neurotoxic effects of chymopapain on peripheral nerves.
    • To evaluate nerve fiber damage following different injection routes of chymopapain.

    Main Methods:

    • Peripheral nerve models were utilized in rat and primate subjects.
    • Chymopapain was administered via extrafascicular and intrafascicular injections.
    • Nerve fiber damage was assessed in a dose-dependent manner.

    Main Results:

    • Extrafascicular injection of chymopapain did not result in nerve fiber damage.
    • Intrafascicular injection of chymopapain caused dose-related nerve fiber damage in both rat and primate models.
    • Findings indicate a direct neurotoxic effect of chymopapain when introduced within the nerve fascicle.

    Conclusions:

    • Chymopapain exhibits neurotoxic properties when injected intrafascicularly.
    • Careful consideration of injection technique is crucial to mitigate neurotoxicity risks associated with chemonucleolysis.
    • Further research may explore alternative enzymes or delivery methods to enhance chemonucleolysis safety.

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