Related Experiment Videos
[Preoperative chemo-embolization for liver cell cancer].
Nihon Geka Gakkai Zasshi
|September 1, 1983
Summary
Transcatheter arterial chemo-embolization (TACE) effectively achieves complete necrosis in liver cancer, potentially preventing intrahepatic spread. This preoperative TACE improves survival rates when combined with hepatic resection for unresectable hepatocellular carcinoma.
Area of Science:
- Hepatobiliary Surgery
- Interventional Radiology
- Oncology
Context:
- Transcatheter arterial chemo-embolization (TACE) is a common treatment for unresectable liver cell cancer.
- Previous studies indicated TACE leads to cancer necrosis.
Purpose:
- To histologically examine resected hepatocellular cancer specimens after TACE.
- To evaluate TACE's efficacy in preventing intrahepatic spread and justify its preoperative use.
Summary:
- Histological examination of 14 resected hepatocellular cancer specimens after TACE.
- TACE followed by hepatic resection showed a 1-year survival rate of 83%, compared to 46% for resection alone and 59% for TACE alone.
- Complete necrosis of capsular invasion was observed in 60% of cases, particularly in smaller tumors (<5 cm), suggesting a benefit in preventing recurrence after resection.
Impact:
- Preoperative TACE demonstrates a significant survival benefit when combined with hepatic resection for unresectable hepatocellular carcinoma.
- The necrotizing effect of TACE on capsular invasion may reduce recurrence risk in high-risk patients undergoing local excision.
- TACE is less effective for bulky tumors with extensive portal vein invasion.