Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Behavioural plasticity and the cholinergic system.

D H Overstreet

    Progress in Neuro-Psychopharmacology & Biological Psychiatry
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gestational ethanol and nicotine exposure: effects on maternal behavior, oxytocin, and offspring ethanol intake in the rat.

    Neurotoxicology and teratology·2008
    Same author

    Withdrawal emotional-regulation in infant rats from genetic animal models of depression.

    Behavioural brain research·2008
    Same author

    Anxiety-like behaviors in pre-pubertal rats of the Flinders Sensitive Line (FSL) and Wistar-Kyoto (WKY) animal models of depression.

    Behavioural brain research·2005
    Same author

    Reward and anxiety in genetic animal models of childhood depression.

    Behavioural brain research·2005
    Same author

    Blunted response to cocaine in the Flinders hypercholinergic animal model of depression.

    Neuroscience·2005
    Same author

    Altered neuroendocrine response and gastric dysmotility in the Flinders Sensitive Line rat.

    Neurogastroenterology and motility·2005
    Same journal

    Altered dorsal striatal subregional connectivity associated with distinct executive function deficits in first-episode, drug-naïve major depressive disorder: Evidence from functional connectivity and granger causality analysis.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Chronic pain and stress: unravelling the common neuroinflammatory, immune and endocrine mechanisms for novel therapeutic approaches.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Predicting anhedonia and negative cognitive processing changes after 8-week SSRIs treatment in depression from individual differential structural covariance network.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Mapping intrinsic neural timescale alterations in major depressive disorder.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Probiotics in reducing negative symptoms of schizophrenia: A systematic review and meta-analysis.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    The IL10 rs1800872 polymorphism differentially modulates the relationship between plasma IL-10 levels and cognitive function in methamphetamine use disorder.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    See all related articles

    The cholinergic system influences learning, memory, and drug tolerance but not habituation. While it shows promise for treating memory deficits, success in aged humans remains limited.

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology
    • Cognitive Science

    Background:

    • The cholinergic system, a key neurotransmitter pathway, plays a crucial role in various brain functions.
    • Behavioral plasticity, encompassing habituation, learning, memory, and tolerance, is essential for adaptation.
    • Understanding the cholinergic system's role in these plastic changes is vital for neurological research.

    Purpose of the Study:

    • To review evidence linking the cholinergic system to different forms of behavioral plasticity.
    • To examine the cholinergic system's involvement in habituation, learning, memory, and drug tolerance.
    • To assess the potential of cholinergic system manipulation for treating memory deficits.

    Main Methods:

    • Review of existing scientific literature on the cholinergic system and behavioral plasticity.

    Related Experiment Videos

  • Analysis of studies involving cholinergic antagonists and agonists in animal models.
  • Examination of research on cholinergic system function in aged animals and humans.

    • Main Results:

    • The cholinergic system does not appear to be involved in habituation.
    • Cholinergic system modulation impacts learning, memory, and drug tolerance development, with receptor alterations noted in tolerance.
    • While cholinergic manipulation shows potential for memory enhancement in animals, its efficacy in aged humans is limited.

    Conclusions:

    • The cholinergic system is integral to learning, memory, and tolerance but not habituation.
    • Further research is needed to fully elucidate the plasticity of the cholinergic system.
    • Clinical application of cholinergic system manipulation for memory deficits in humans requires further investigation.