Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anesthesia-associated depression in lymphocyte traffic and its modulation.

T C Moore

    American Journal of Surgery
    |June 1, 1984
    PubMed
    Summary

    Anesthetics significantly reduce lymphocyte traffic, a effect modulated by inflammation and specific agents. This impacts immune cell movement during and after surgery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Collaborative engagement with vector control stakeholders is key to enhance the utility of vector-borne disease models.

    Parasites & vectors·2025
    Same author

    Iron-plasma transmission measurements at temperatures above 150 eV.

    Physical review letters·2008
    Same author

    Hot dense capsule-implosion cores produced by Z-pinch dynamic Hohlraum radiation.

    Physical review letters·2004
    Same author

    X-ray imaging measurements of capsule implosions driven by a Z-pinch dynamic hohlraum.

    Physical review letters·2002
    Same author

    Successful use of the "patch, drain, and wait" laparotomy approach to perforated necrotizing enterocolitis: is hypoxia-triggered "good angiogenesis" involved?

    Pediatric surgery international·2000
    Same author

    Pre-term and particularly pre-labor cesarean section to avoid complications of gastroschisis.

    Pediatric surgery international·1999

    Area of Science:

    • Immunology
    • Anesthesiology
    • Surgical Science

    Background:

    • Anesthesia and surgical procedures can impact immune cell function.
    • Lymphocyte traffic is crucial for immune surveillance and response.

    Purpose of the Study:

    • To investigate the effects of anesthetic agents on lymphocyte output in efferent lymph.
    • To determine the influence of surgical trauma, inflammation, and specific agents on anesthesia-induced changes in lymphocyte traffic.

    Main Methods:

    • Studied general and local anesthetic agents in surgical contexts.
    • Monitored lymphocyte output in efferent lymph.
    • Investigated the effects of inflammation and infused agents (bradykinin, 8-bromo cyclic guanosine monophosphate) on lymphocyte traffic.

    Main Results:

    • All tested anesthetics caused significant, dose-dependent reductions in lymphocyte traffic.
    • Surgical trauma did not correlate with the degree of lymphocyte depression.
    • Inflammation and infusion of bradykinin or 8-bromo cyclic guanosine monophosphate modulated and increased lymphocyte traffic.

    Conclusions:

    • Anesthetic agents profoundly suppress lymphocyte traffic, independent of surgical trauma.
    • Inflammatory processes and specific signaling molecules can counteract anesthesia-induced immunosuppression.
    • Understanding these modulatory effects is key for managing immune function during surgical interventions.

    Related Experiment Videos