Histamine and parathyroid activity

The effect of histamine on parathyroid function was studied in two patients. 2.75 mg histamine phosphate administered intravenously over 120 minutes induced the well known clinical effects such as facial flushing, fall in blood pressure and increase in heart rate. But the serum calcium concentration, serum immunoreactive parathormone concentration, urinary excretion of cAMP and tubular phosphate reabsorption did not change significantly. It is concluded that stimulation of histamine receptors does not play an important role in the regulation of parathyroid activity.