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Histamine and parathyroid activity.

P C Van der Velden, M A Naafs, J H Paulusma-de Waal

    Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
    |May 1, 1984
    PubMed
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    Histamine administration did not significantly alter parathyroid function markers like serum calcium or parathormone. These findings suggest histamine receptors are not crucial for regulating parathyroid activity.

    Area of Science:

    • Endocrinology
    • Pharmacology

    Background:

    • Histamine is a biogenic amine with diverse physiological roles.
    • Its potential influence on parathyroid gland function remains incompletely understood.

    Purpose of the Study:

    • To investigate the effect of histamine stimulation on parathyroid gland function in humans.

    Main Methods:

    • Two patients received intravenous histamine phosphate (2.75 mg over 120 minutes).
    • Clinical effects (flushing, blood pressure, heart rate) were monitored.
    • Serum calcium, serum immunoreactive parathormone, urinary cAMP, and tubular phosphate reabsorption were measured.

    Main Results:

    • Histamine induced expected systemic effects, including flushing, hypotension, and tachycardia.

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  • No significant changes were observed in serum calcium levels.
  • Serum immunoreactive parathormone, urinary cAMP excretion, and tubular phosphate reabsorption remained unchanged.

    • Conclusions:

    • Histamine receptor stimulation does not appear to play a significant role in the regulation of parathyroid gland activity.
    • These results indicate that histamine is unlikely to be a major regulator of calcium homeostasis via the parathyroid glands.