Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histamine and the heart.

J H McNeill

    Canadian Journal of Physiology and Pharmacology
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Histamine receptors (H1 and H2) are present in various animal hearts, with specific locations differing by species. These receptors influence heart function through distinct mechanisms, impacting calcium ion concentration.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin-resistant rats.

    British journal of pharmacology·2011
    Same author

    Endothelin-1 modulates angiotensin II in the development of hypertension in fructose-fed rats.

    Molecular and cellular biochemistry·2009
    Same author

    The effects of vanadium treatment on bone in diabetic and non-diabetic rats.

    Bone·2005
    Same author

    Alterations in the vascular actions of insulin in the pathogenesis of insulin resistance and hypertension.

    Advances in experimental medicine and biology·2002
    Same author

    Vanadium compounds as insulin mimics.

    Chemical reviews·2001
    Same author

    In vivo effects of vanadium in diabetic rats are independent of changes in PI-3 kinase activity in skeletal muscle.

    Molecular and cellular biochemistry·2001
    Same journal

    Next-generation therapeutics and renaissance of legacy drugs targeting the endothelin system.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    Exploring the causal relationship between inflammatory cytokines and diabetic foot ulcer: A bidirectional Mendelian randomization and clinical validation study.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    TRPV1, Endocannabinoid, and Opioid Systems in Analgesia: Molecular Mechanisms and Drug Development Strategies.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    Association of stromal cell derived factor 1α and interferon-γ induced protein 10 with Fontan pathophysiology.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    Incretins for Type 2 Diabetes.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    Glucagon-like peptide 1 receptor agonists: anti-inflammatory effects in cardiovascular diseases.

    Canadian journal of physiology and pharmacology·2026
    See all related articles

    Area of Science:

    • Cardiology
    • Pharmacology
    • Molecular Biology

    Background:

    • Histamine has been recognized as a cardiac stimulant for over 70 years.
    • Previous research has indicated the presence of histamine receptors in mammalian hearts.

    Purpose of the Study:

    • To investigate the distribution and types of histamine receptors in the hearts of various species.
    • To elucidate the functional roles and signaling pathways associated with cardiac histamine receptors.

    Main Methods:

    • Comparative analysis of histamine receptor distribution across different species' cardiac tissues (guinea pig, rabbit, rat, cat, dog, human).
    • Investigation of receptor-mediated signaling pathways, including adenylate cyclase activity and cyclic AMP levels.
    • Examination of the relationship between histamine receptor stimulation and intracellular calcium ion concentration.

    Related Experiment Videos

    Main Results:

    • Histamine receptor types (H1 and H2) vary significantly between species and within different regions of the same heart.
    • In guinea pigs, H1 receptors are in left atria/ventricles, H2 in right atria; ventricles have predominant H2. Rabbits have both H1 and H2 in atria, only H1 in ventricles.
    • Rat and cat hearts lack direct histamine receptors; effects are mediated by noradrenaline release. Dog hearts possess H1 receptors, while human hearts have H2 receptors.
    • H2 receptors are linked to adenylate cyclase, increasing cyclic AMP. H1 receptors are not associated with cyclic nucleotides.
    • Both H1 and H2 receptor stimulation increase intracellular calcium, but via different mechanisms.

    Conclusions:

    • Cardiac histamine receptor distribution is species-specific and regionally differentiated.
    • H2 receptors activate the cyclic AMP pathway, while H1 receptors operate through a separate mechanism.
    • Histamine's cardiac effects are mediated by distinct H1 and H2 receptor subtypes, with functional similarities to adrenergic receptors.