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Updated: Aug 8, 2026
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Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins
Published on: November 18, 2016
Summary
Von Willebrand's disease is a common inherited bleeding disorder in dogs, causing mild symptoms like bleeding and lameness. Breeding affected dogs or carriers is discouraged due to its genetic nature.
Area of Science:
- Veterinary Medicine
- Genetics
- Hematology
Background:
- Von Willebrand's disease is the most prevalent inherited bleeding disorder in animals, particularly affecting various dog breeds.
- This autosomal condition typically results in high morbidity with low mortality rates.
Purpose of the Study:
- To summarize the key aspects of Von Willebrand's disease in dogs.
- To outline clinical signs, exacerbating factors, genetic considerations, and treatment strategies.
Main Methods:
- Review of clinical signs associated with Von Willebrand's disease.
- Discussion of genetic inheritance patterns and breeding recommendations.
- Overview of current treatment modalities and preventative measures.
Main Results:
- Clinical signs include hematuria, epistaxis, mucosal bleeding, lameness, and prolonged bleeding from wounds or nails.
- Concurrent hypothyroidism can worsen the disease.
- Testing for von Willebrand factor is recommended before breeding dogs.
Conclusions:
- Affected dogs and carriers should not be bred.
- Treatment involves fresh whole blood or plasma transfusions and hemostatic agents.
- Avoiding drugs that interfere with hemostasis is crucial for managing the condition.
