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Related Experiment Videos

Transfer factor and repeated otitis media.

J Kaminkova, C F Lange

    Cellular Immunology
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Transfer factor (TF) therapy improved immune cell function in children with recurrent otitis media. TF treatment boosted T-cell activity and monocyte function, leading to fewer infections.

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    Area of Science:

    • Immunology
    • Pediatrics
    • Otolaryngology

    Background:

    • Recurrent otitis media is a common childhood illness often associated with immune system deficiencies.
    • Understanding the immunological profile of children with recurrent otitis media is crucial for effective treatment strategies.

    Purpose of the Study:

    • To investigate the immunomodulatory effects of transfer factor (TF) therapy in children suffering from recurrent otitis media.
    • To assess changes in immune cell function, including T-cells and phagocytic activity, following TF administration.
    • To evaluate the clinical efficacy of TF therapy in reducing the frequency and severity of otitis media episodes.

    Main Methods:

    • Immunological parameters including immunoglobulin levels, T-cell counts (total and active), and phagocytic activity of granulocytes and monocytes were measured in 12 children with recurrent otitis media.

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  • These measurements were taken before, during, and after a course of transfer factor (TF) therapy.
  • The patient group was immunologically compared to a control group of 23 age-matched healthy children.

    • Main Results:

    • TF therapy significantly increased the percentages and absolute numbers of 'active' T cells and total T cells in patients, bringing them to levels comparable to healthy controls.
    • Phagocytic activity of monocytes in patients post-therapy normalized to control levels, while phagocytic activity of granulocytes remained significantly depressed.
    • Immunoglobulin levels (IgG, IgA, IgM) were not significantly affected by TF therapy, though IgA and IgM were higher in patients throughout the study.
    • Following TF therapy, 50% of the children remained asymptomatic for one year, and the remaining patients experienced a marked reduction in otitis media attack rates.

    Conclusions:

    • Transfer factor (TF) therapy demonstrates significant immunomodulatory effects in children with recurrent otitis media, particularly by enhancing T-cell mediated immunity.
    • TF therapy shows clinical benefit, leading to prolonged asymptomatic periods and reduced infection rates in a subset of treated children.
    • While TF therapy improves certain immune functions, persistent deficits in granulocyte phagocytic activity warrant further investigation.