Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Association between diet-exercise patterns and central obesity in students in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Congenital systemic artery to pulmonary artery fistulas causing massive hemoptysis in a child interventional therapy using thermosensitive liquid embolic agent].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2026
Same author

[Comparison and inspiration of occupational disease lists caused by physical factors at home and abroad].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2025
Same author

[Efficacy and prognostic factors of split liver transplantation from pediatric donors].

Zhonghua yi xue za zhi·2025
Same author

[Transcatheter aortic valve replacement for aortic valve regurgitation after left ventricular assist device implantation: a case report].

Zhonghua xin xue guan bing za zhi·2025
Same author

[Analysis of risk factors for post-prematurity respiratory disease in very preterm infants].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2024
Same journal

[Mechanical regulation mechanism on vascular remodeling induced by hypertension].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[Progress on research methods of transcription factors].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[Regulatory effect of miR-21 on peripheral nerve injury and regulation function].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[The protective effects and mechanisms of PPARγ in ischemia-reperfusion injury of tissues].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[Nitric Oxide Signaling Pathway and Vascular Activity].

Sheng li ke xue jin zhan [Progress in physiology]·2018
Same journal

[The Regulation Effects of Carbon Monoxide in Cardiovascular Systems].

Sheng li ke xue jin zhan [Progress in physiology]·2018
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

[Epidermal growth factor-urogastrone]

J F Zhang, Y S Guo

    Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
    |April 1, 1984
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
    06:01

    Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

    Published on: October 6, 2022

    Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
    08:28

    Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

    Published on: May 9, 2025

    Related Experiment Videos

    Last Updated: Jun 19, 2026

    Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
    05:56

    Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

    Published on: January 22, 2020

    Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
    06:01

    Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

    Published on: October 6, 2022

    Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
    08:28

    Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

    Published on: May 9, 2025