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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
Pathogenicity of Branhamella catarrhalis
Acta Oto-Laryngologica. Supplementum
|January 1, 1984
Summary
Branhamella catarrhalis, once thought harmless, is now recognized as a cause of various infections. Antibiotic resistance is increasing, necessitating alternative treatments like erythromycin and co-trimoxazole for resistant strains.
Area of Science:
- Microbiology
- Infectious Diseases
Background:
- Branhamella catarrhalis is a Gram-negative diplococcus distinct from other Neisseriaceae.
- Historically considered a pharyngeal commensal, recent evidence highlights its pathogenic potential.
Purpose of the Study:
- To review the evolving understanding of Branhamella catarrhalis pathogenicity.
- To discuss antibiotic susceptibility and resistance patterns.
Main Methods:
- Literature review of reported cases and etiological roles.
- Analysis of antibiotic susceptibility data, including beta-lactamase production.
Main Results:
- B. catarrhalis is implicated in otitis media, bronchopulmonary infections, sinusitis, and laryngitis.
- While generally susceptible to various antibiotics, a significant increase in beta-lactamase producing strains (from 4% to 25%) has been observed.
Conclusions:
- B. catarrhalis is an emerging pathogen in respiratory and other infections.
- Erythromycin and co-trimoxazole are recommended first-line treatments for infections caused by penicillin-resistant strains.
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