Histocompatibility antigen patterns in Dupuytren's contracture

Thirty-seven consecutive patients with Dupuytren's Contracture were investigated by tissue typing techniques to ascertain their HLA--A, B, C and DR antigen status. Whilst no definite HLA antigen was found in association with this disease, at least one possibly significant pattern of HLA DR antigens was found in these patients. This finding was also noted in patients with scleroderma, and the scleroderma-like syndrome induced by vinyl chloride exposure.