Preliminary amino acid sequences of transplantation antigens: genetic and evolutionary implications

Preliminary amino acid sequence data on the transplantation antigens of mouse and man have led to provocative hypotheses about the genetic organization and evolution of genes coded by the major histocompatibility complex of mammals. New microsequencing techniques should permit a detailed analysis of these gene products and an eventual choice among the alternative hypotheses now posed. These data have made it apparent that the H-2 complex is a fascinating and complicated chromosomal region which will continue for some time to intrigue immunologists, geneticists, biochemists, and cell biologists.