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In search for the egocentric reference. A neurophysiological hypothesis.

J Ventre, J M Flandrin, M Jeannerod

    Neuropsychologia
    |January 1, 1984
    PubMed
    Summary

    Unilateral lesions in cat parietal cortex or superior colliculus weaken the vestibulo-ocular reflex. Symmetrical responses recover within weeks, suggesting a displaced internal reference for spatial behavior.

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    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Vestibular System

    Background:

    • The vestibulo-ocular reflex (VOR) stabilizes gaze during head movements.
    • The parietal cortex and superior colliculus are implicated in spatial processing and motor control.
    • Unilateral brain lesions can lead to sensory and motor deficits, including spatial neglect.

    Purpose of the Study:

    • To investigate the effects of unilateral lesions in the feline parietal cortex and superior colliculus on the vestibulo-ocular reflex.
    • To explore the role of these brain regions in maintaining symmetrical VOR responses.
    • To relate findings to the concept of an internal reference for extrapersonal space and clinical symptoms in humans.

    Main Methods:

    • Induction of unilateral lesions in the middle suprasylvian gyrus of the parietal cortex in cats.
    • Induction of unilateral lesions in the superior colliculus in cats.
    • Assessment of vestibulo-ocular reflex symmetry before and after lesioning.

    Main Results:

    • Unilateral lesions of the middle suprasylvian gyrus resulted in an asymmetrical VOR, with weaker responses to head rotation away from the lesion.
    • Unilateral lesions of the superior colliculus produced similar asymmetrical VOR responses.
    • Symmetrical VOR responses were recovered within 2-3 weeks post-lesioning in both cases.

    Conclusions:

    • Unilateral lesions in the parietal cortex or superior colliculus disrupt the VOR by displacing an internal spatial reference.
    • The recovery of symmetrical responses suggests adaptive mechanisms or compensation.
    • These findings offer insights into human unilateral neglect following posterior parietal lesions.

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