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Updated: Aug 11, 2026

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
Published on: July 16, 2012
Anti-inflammatory and analgesic properties of four amino-acids
Abstract:
Orally administered L-isoleucine, DL-isoleucine and L-leucine exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only. L-isoleucine also exhibited prolonged analgesic effect while DL-isoleucine had a short lasting effect. The amino-acids produced no gastric ulceration or overt acute toxicity in doses which effectively suppress inflammation. Anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.
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