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Nociceptive circling and naloxone
R Rabinowitz1, N Shlesinger, A D Korczyn
1Dept. of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Pharmacological Research Communications
|November 1, 1983
Summary
Mice show turning behavior that intensifies with electric foot stimulation. This suggests enkephalins, potentially released during stimulation, influence this rotatory behavior in mice.
Area of Science:
- Neuroscience
- Animal Behavior
- Pharmacology
Background:
- Mice naturally exhibit directional rotatory behavior under certain conditions.
- Understanding the neurobiological underpinnings of such behaviors is crucial for neurological research.
Purpose of the Study:
- To investigate the effect of noxious electric foot stimulation on the rotatory behavior of mice.
- To explore the potential role of endogenous opioids, specifically enkephalins, in modulating this behavior.
Main Methods:
- Observation and quantification of rotatory behavior in mice.
- Application of noxious electric stimulation to the feet of mice.
- Administration of naloxone, an opioid antagonist, prior to stimulation.
Main Results:
- Electric foot stimulation significantly increased the rate of turning in mice.
- Stimulation also altered the ratio of circling in preferred versus opposite directions.
- Naloxone administration tended to counteract the effects of electric stimulation on rotatory behavior.
Conclusions:
- Noxious electric stimulation appears to modulate rotatory behavior in mice.
- The observed effects suggest the involvement of enkephalin release during stimulation.
- Enkephalins may play a role in influencing directional turning behavior in response to noxious stimuli.