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Related Experiment Videos

Growth after renal transplants.

M Bosque, A Munian, M Bewick

    Archives of Disease in Childhood
    |February 1, 1983
    PubMed
    Summary

    Children receiving renal transplants on alternate-day prednisolone showed normal growth expectations. Many experienced accelerated growth, indicating preserved growth potential post-transplant.

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    Area of Science:

    • Pediatric Nephrology
    • Transplantation Immunology
    • Growth and Development

    Background:

    • Renal transplantation is a critical intervention for children with end-stage renal disease.
    • Optimizing post-transplant growth remains a significant challenge in pediatric care.
    • Alternate-day prednisolone regimens are used to manage immunosuppression.

    Purpose of the Study:

    • To analyze the growth expectations of children undergoing renal transplantation.
    • To evaluate the impact of alternate-day prednisolone on growth in pediatric renal transplant recipients.
    • To determine if growth potential is maintained in this patient population.

    Main Methods:

    • Retrospective analysis of 46 children (bone age < 15 years) who received their first renal transplant between 1975-1980.
    • Growth was assessed using standard deviation scores comparing height at transplant to height at the end of 1981.
    • Evaluated growth per year of bone age advancement and chronological age.

    Main Results:

    • Overall growth was normal (mean SD score: +0.7 for boys, -0.3 for girls) in 41 children with functioning grafts.
    • Twenty-five children exhibited accelerated growth.
    • No significant loss of growth potential was observed (mean SD score per year of bone age advance: +0.003).
    • Boys with a bone age < 12 years at transplant showed better growth per chronological age year, linked to initial growth deficit.
    • Glomerular filtration rate, prednisolone dose, and phosphate levels did not impact growth in 11 prepubertal children.

    Conclusions:

    • Pediatric renal transplant recipients on alternate-day prednisolone can achieve normal growth expectations.
    • The study suggests preserved growth potential and potential for catch-up growth post-transplantation.
    • Early bone age and initial growth deficit may influence growth trajectories in boys.

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