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Updated: Dec 23, 2025

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
Published on: November 11, 2021
Physiologic regulation of body energy storage
Abstract:
Both new and published data (rats, mice, and human beings) on three parameters--fat mass, fat-free body mass (FFBM), and total body mass in some cases--are evaluated. Steady state values of the parameters are analyzed for changes in response to specific perturbing agents and for their frequency distributions. Temporal sequences of values on individuals are examined for evidence of regulatory responses. The results lead to the hypothesis that the FFBM is regulated, but probably not as a unit, and that mass of fat is regulated with a high priority near the range extremes but with a much lower priority in the mid-range. Properties and advantages of such a mechanism are discussed.
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