Initiation and direction of polymorphonuclear leucocyte locomotion. The particle collision hypothesis

A simple model of the initiation of locomotion, the random movement and the directional locomotion during chemotaxis is derived from observations on moving human polymorphonuclear leucocytes (PMNs). This model provides a unifying concept of initiation of PMN locomotion, PMN random movement and PMN chemotaxis. The lamellipodium is thought to be the direction-determining cell organelle.