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Published on: March 14, 2017
Effect of parathyroid hormone on renin secretion
Summary
Parathyroid hormone (PTH) infusion increased renin secretion systemically in dogs. However, direct renal artery infusion of PTH did not elevate renin secretion, suggesting an indirect mechanism for PTH's effect on renin.
Area of Science:
- Nephrology
- Endocrinology
- Physiology
Background:
- Parathyroid hormone (PTH) plays a crucial role in calcium and phosphate homeostasis.
- The systemic effects of PTH on renin secretion are known, but the direct renal mechanisms are unclear.
Purpose of the Study:
- To investigate whether parathyroid hormone (PTH) directly stimulates renin secretion from the kidney.
- To elucidate the direct renal action of PTH on renin release.
Main Methods:
- Intravenous infusion of bovine PTH 1-34 in anesthetized dogs to assess systemic effects.
- Direct infusion of PTH into the renal artery to evaluate localized renal effects on renin secretion.
- Measurement of renin secretion rates from both infused and control kidneys.
- Analysis of renal excretion rates of phosphate and sodium.
Main Results:
- Systemic intravenous PTH infusion significantly increased overall renin secretion by 149%.
- Direct intra-renal artery infusion of PTH did not increase renin secretion from the infused kidney compared to the control kidney.
- PTH infusion into the renal artery increased phosphate and sodium excretion from the infused kidney.
Conclusions:
- Parathyroid hormone (PTH) does not directly stimulate renin secretion via a direct action on the kidney.
- PTH's effect on increasing renin secretion appears to be mediated by indirect systemic mechanisms.
- PTH directly influences renal tubular function, increasing phosphate and sodium excretion.
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