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Related Experiment Videos

Ocular and orbital involvement in leukemia.

M C Kincaid, W R Green

    Survey of Ophthalmology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Leukemia can affect eye tissues through infiltration, bleeding, or ischemia. Ophthalmologists must recognize these ocular signs for accurate leukemia prognosis and management.

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    Area of Science:

    • Ophthalmology
    • Hematology
    • Oncology

    Background:

    • Leukemia, a cancer of blood-forming tissues, can manifest ocular complications.
    • Ocular involvement in leukemia can occur through direct infiltration, hemorrhage, or ischemic events.
    • Both acute and chronic leukemia present with distinct ocular signs and symptoms.

    Purpose of the Study:

    • To review the clinical features and pathological correlations of ocular involvement in leukemia.
    • To discuss the ocular toxicity associated with leukemia chemotherapy.
    • To highlight the ophthalmic implications of bone marrow transplantation complications, such as graft-versus-host disease and dry eyes.

    Main Methods:

    • Literature review of ocular manifestations in leukemia.
    • Analysis of pathological correlations between leukemia and ocular tissues.

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  • Discussion of treatment-related ocular toxicities and complications.

    • Main Results:

    • Leukemia can infiltrate virtually any ocular tissue, leading to diverse visual impairments.
    • Chemotherapeutic agents used for leukemia treatment can induce significant ocular toxicity.
    • Graft-versus-host disease post-bone marrow transplant may result in dry eyes (alacrima) due to immunosuppression.

    Conclusions:

    • Ophthalmologists play a crucial role in identifying ocular signs of leukemia.
    • Early recognition of ocular involvement aids in assessing leukemia's course and prognosis.
    • Comprehensive understanding of leukemia's ocular impact is vital for patient care and management.