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Related Experiment Videos

Exercise-induced airway obstruction.

E R McFadden, R H Ingram

    Annual Review of Physiology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Respiratory heat loss causing airway cooling is linked to exercise-induced asthma (EIAO) severity. Further research will explore multifactorial mechanisms and nonspecific airway responsiveness.

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    Area of Science:

    • Respiratory physiology
    • Exercise-induced asthma pathophysiology

    Background:

    • Previous discrepancies in exercise-induced asthma (EIAO) pathophysiology are reconciled by airway cooling.
    • Airway cooling, resulting from respiratory heat loss, directly correlates with EIAO occurrence and severity.

    Purpose of the Study:

    • To reconcile conflicting theories on EIAO pathophysiology.
    • To investigate the role of airway cooling in EIAO.
    • To explore the mechanisms underlying airway cooling-induced responses.

    Main Methods:

    • Documenting and quantitating historical observations on respiratory heat loss.
    • Investigating mediator release and vago-vagal reflexes in response to airway cooling.
    • Studying the effects of cooling on airway smooth muscle responsiveness and metabolism.

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    Main Results:

    • Airway cooling is causally linked to the occurrence and magnitude of airway obstruction in EIAO.
    • Recent measurements confirm historical observations regarding respiratory heat loss.
    • Controversy persists regarding mediator release and vago-vagal reflexes.

    Conclusions:

    • Airway cooling is a significant factor in EIAO pathophysiology.
    • The response to airway cooling is likely multifactorial, involving diverse processes.
    • Further research is needed to understand the complex interplay of factors contributing to EIAO.