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Glucose tolerance in aging obese (ob/ob) and lean mice
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|March 1, 1983
Summary
Stressful procedures, not added glucose, cause hyperglycemia in obese mice. Hormone levels like glucagon, corticosterone, and insulin do not fully explain this stress response.
Area of Science:
- Endocrinology
- Metabolic Research
- Animal Models
Background:
- Obesity is linked to impaired glucose metabolism.
- Stress can exacerbate hyperglycemia, but the mechanisms are not fully understood.
Purpose of the Study:
- To investigate the causes of hyperglycemia in obese mice.
- To determine the contribution of stress from procedures versus glucose load to hyperglycemia.
- To explore the role of key hormones in stress-induced hyperglycemia.
Main Methods:
- Glucose tolerance tests were performed on younger and older obese mice.
- Simultaneous measurements of circulating glucagon, corticosterone, and insulin were conducted.
- Analysis focused on glucose responses to injection/bleeding versus added glucose.
Main Results:
- Hyperglycemia in obese mice was primarily driven by responses to injection and bleeding procedures.
- The added glucose load contributed less to post-injection hyperglycemia.
- Differences in basal hormone levels, ratios, or response magnitudes did not fully explain the observed stress hyperglycemia.
Conclusions:
- Procedure-induced stress significantly contributes to hyperglycemia in obese mice.
- Hormonal dysregulation alone does not account for the full extent of stress-induced hyperglycemia.
- Further research is needed to elucidate the complete mechanisms of stress hyperglycemia in obesity.