Orbital aspergillosis

We treated a 40-year-old male who had orbital aspergillosis and presumed early intracranial extension with limited orbital exenteration and adjunctive amphotericin B. Forty-two months later the patient is alive without recurrence. Our patient illustrates the typical presentation of orbital aspergillosis with severe periorbital pain and proptosis; however, he did not have the usual concomitant sinusitis. Aggressive surgical and antifungal therapy in this case was successful in preventing further intracranial extension, which usually has a high mortality rate.