Related Experiment Video
Updated: Sep 19, 2026
A Procedure for Implanting a Spinal Chamber for Longitudinal In Vivo Imaging of the Mouse Spinal Cord
Published on: December 3, 2014
Amipaque myelography without late adhesive arachnoid changes
Abstract:
Sixty-three myelographies were performed with Amipaque. Remyelography after an interval of longer than 2 months showed that in one case there was progression of an arachnoiditis which had already been present during the first Amipaque study. In one other case there were minimal, unilateral nerve root changes caused by an intervening operation. Altogether 269 remyelographies without secondary late reactions are registered. Two cases of increased arachnoid changes from a previous myelography with another contrast medium hardly can be due to Amipaque.
Insights
Remyelography using Amipaque showed minimal adverse effects in most cases. Only two patients experienced worsening arachnoiditis, with one case potentially linked to a prior operation, not the contrast agent.
Area of Science:
- Radiology
- Neurology
- Medical Imaging
Background:
- Myelography is a diagnostic imaging technique.
- Amipaque is a contrast medium used in myelography.
- Assessing the safety and long-term effects of contrast media is crucial.
Purpose of the Study:
- To evaluate the safety and incidence of late adverse reactions following Amipaque myelography.
- To assess the impact of repeat myelography (remyelography) with Amipaque.
Main Methods:
- Performed sixty-three myelographies using Amipaque.
- Conducted remyelographies in a subset of patients after an interval of over two months.
- Registered 269 remyelographies, noting any secondary late reactions.
Main Results:
- One case showed progression of pre-existing arachnoiditis during remyelography.
- One case exhibited minimal nerve root changes attributed to a subsequent operation.
- No secondary late reactions were registered in 269 remyelographies.
- Two cases of increased arachnoid changes possibly related to prior non-Amipaque contrast media were observed.
Conclusions:
- Remyelography with Amipaque appears to have a low incidence of significant late adverse reactions.
- Observed arachnoid changes in remyelography cases were generally not attributable to Amipaque itself, with other factors like prior operations or different contrast agents being more likely causes.
