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Related Experiment Videos

Dihydroergotamine in postoperative ileus.

J Thorup, P Wille-Jørgensen, T Jørgensen

    Clinical Pharmacology and Therapeutics
    |July 1, 1983
    PubMed
    Summary
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    Dihydroergotamine (DHE) did not significantly reduce postoperative ileus duration in patients undergoing major abdominal surgery. This study found no difference in recovery of bowel function or laxative use between DHE and control groups.

    Area of Science:

    • Gastroenterology
    • Surgical Outcomes
    • Pharmacology

    Background:

    • Postoperative ileus is a common complication following major abdominal surgery, leading to increased hospital stays and costs.
    • Pharmacological interventions are sought to mitigate the duration and severity of postoperative ileus.
    • Dihydroergotamine (DHE) is a medication with potential effects on gastrointestinal motility.

    Purpose of the Study:

    • To investigate the efficacy of dihydroergotamine (DHE) in reducing the duration of postoperative ileus after major abdominal surgery.
    • To compare the time to first flatus, first stool, and laxative requirements in patients receiving DHE versus a control group.

    Main Methods:

    • A randomized controlled trial involving 74 patients undergoing major abdominal surgery.

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  • Forty-one patients received subcutaneous dihydroergotamine (DHE) 0.5 mg twice daily from the day of surgery to postoperative day seven.
  • Thirty-three patients received a placebo and served as the control group.

    • Main Results:

    • No statistically significant difference was observed in the time to the first postoperative passage of flatus between the DHE and control groups.
    • There was no significant difference in the time to the first delivery of stools between the two groups.
    • The quantity of laxatives administered was comparable between patients treated with DHE and the control group.

    Conclusions:

    • Dihydroergotamine (DHE) administered subcutaneously does not appear to be effective in reducing the duration of postoperative ileus following major abdominal surgery.
    • Further research may be needed to explore other pharmacological agents or multimodal approaches for managing postoperative ileus.
    • The findings suggest that DHE is not a beneficial treatment for preventing or shortening the duration of postoperative ileus in this patient population.