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Updated: Aug 4, 2026

Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic
Published on: September 4, 2012
[Experimental mastitis in cows caused by Staphylococci, Streptococci and Corynebacteria]
Abstract:
Mastitis was experimentally induced in seven cows of the Black-and-white breed through the intramammary or i/v application of bacterial cultures of the encapsulated variant of Staph. epidermidis as well as of Str. agalactiae and Cor. pyogenes. The disease ran a course with high body temperature, strongly manifested inflammatory changes in the mammary gland, and altered phagocytic activity. It was found that the introduction into the mammary gland of a 'stable-specific' bovine blood serum in combination with the preparation nitrofuridine (a Shiff base of the 5-nitrofurfurol with sulfaguanidine) which boosts the phagocytic activity, had produced a therapeutic effect.
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