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[Nucleoside polyphosphates: occurrence, metabolism and function].

K Riedel

    Zeitschrift Fur Allgemeine Mikrobiologie
    |January 1, 1983
    PubMed
    Summary
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    Nucleoside polyphosphates mediate metabolic changes in prokaryotes, enabling adaptation to nutrient availability and development. This review details their role in the stringent response and broader cellular regulation.

    Area of Science:

    • Microbiology
    • Molecular Biology
    • Biochemistry

    Context:

    • Prokaryotes possess sophisticated regulatory systems to adapt metabolism to environmental changes, such as nutrient availability.
    • These systems allow for growth reduction and the initiation of developmental processes.
    • Nucleoside polyphosphates act as key signaling molecules in these adaptive responses.

    Purpose:

    • To review the characteristics, occurrence, and metabolism of nucleoside polyphosphates.
    • To elucidate the role of nucleoside polyphosphates as mediators of coordinated metabolic alterations in prokaryotes.
    • To explore the pleiotropic effects of these molecules on various cellular processes.

    Summary:

    • This review focuses on nucleoside polyphosphates, which are crucial mediators of metabolic adjustments in prokaryotes.

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  • It covers their metabolism, occurrence, and the stringent response, a key regulatory mechanism.
  • The pleiotropic effects discussed include regulation of protein synthesis, metabolism, cell structure, and development.

    • Impact:

    • Provides a comprehensive overview of nucleoside polyphosphate signaling in prokaryotic adaptation.
    • Highlights the central role of these molecules in coordinating complex cellular responses.
    • Offers insights into the fundamental mechanisms governing microbial survival and development under varying conditions.