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Epidermal changes in lichen planus.

H Ebner, W Gebhart

    Journal of Cutaneous Pathology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Ultrastructural study of lichen planus (LP) reveals basal cell injury is key. Tissue repair in LP may involve unaffected cells within the lesion, not just margins.

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    Area of Science:

    • Dermatology
    • Cell Biology
    • Pathology

    Background:

    • Lichen planus (LP) is an inflammatory condition affecting skin and mucous membranes.
    • Previous studies suggest epidermal changes in LP, but the primary cellular events remain debated.

    Purpose of the Study:

    • To investigate the ultrastructural changes in the epidermis of patients with lichen planus.
    • To elucidate the primary cellular events and potential repair mechanisms in LP.

    Main Methods:

    • Ultrastructural analysis of epidermal biopsies from 15 patients diagnosed with lichen planus.
    • Detailed microscopic examination focusing on basal lamina, basal keratinocytes, and other cellular components.

    Main Results:

    • Consistent findings included basal lamina abnormalities (multiplication, folding, dislocation).

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  • Degenerative changes and fragmentation of basal keratinocytes were observed.
  • Numerous Civatte bodies and dyskeratotic cells were present, alongside mitotic figures of keratinocytes and Langerhans cells.

    • Conclusions:

    • The primary event in lichen planus appears to be injury to epidermal basal cells.
    • Tissue regeneration in LP may originate from unaffected cells within the lesion, in addition to margins and skin appendages.