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Related Experiment Videos

A controlled trial of cinromide.

J W Allen, M J Hamilton, J Oxley

    Epilepsia
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Cinromide was tested in a study for refractory epilepsy. The double-blind controlled trial found no significant antiepileptic effects, even at maximum tolerated doses.

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    Impact of generic substitution of anticonvulsants on the treatment of epilepsy.

    CNS drugs·2013

    Area of Science:

    • Neurology
    • Clinical Pharmacology

    Background:

    • Refractory epilepsy presents significant treatment challenges.
    • Identifying novel antiepileptic drugs (AEDs) is crucial.

    Purpose of the Study:

    • To evaluate the efficacy of cinromide as an antiepileptic agent.
    • To assess the safety and tolerability of cinromide in patients with refractory epilepsy.

    Main Methods:

    • A double-blind, placebo-controlled trial was conducted.
    • Twenty-five adult subjects with refractory epilepsy participated.
    • Maximum tolerated doses of cinromide were administered.

    Main Results:

    • Cinromide demonstrated no significant antiepileptic properties.
    • The study assessed seizure frequency and severity.
  • No significant therapeutic benefit was observed.

    • Conclusions:

    • Cinromide is not effective for treating refractory epilepsy.
    • Further research into cinromide's therapeutic potential is not warranted for epilepsy.