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Insulin pumps and insulin quality--requirements and problems
Acta Medica Scandinavica. Supplementum
|January 1, 1983
Summary
Calcium ions stabilize neutral insulin solutions for delivery devices. This method improves physical stability against heat precipitation without compromising chemical or biological quality, unlike sugar additives.
Area of Science:
- Pharmaceutical Science
- Biochemistry
- Materials Science
Background:
- Developing stable insulin solutions for delivery devices requires balancing physical, chemical, and biological stability.
- Monosaccharides and disaccharides improve physical stability but negatively impact chemical and biological stability.
- Existing stabilization methods may compromise insulin quality.
Purpose of the Study:
- To identify a physiologically acceptable method for stabilizing neutral insulin solutions.
- To enhance the physical stability of insulin solutions against heat precipitation.
- To ensure chemical and biological stability are not adversely affected.
Main Methods:
- Investigated the effect of Ca-ions at low concentrations on neutral insulin solutions.
- Assessed physical stability concerning heat precipitation.
- Evaluated chemical and biological stability of insulin solutions with Ca-ions.
Main Results:
- Addition of Ca-ions effectively stabilized neutral insulin solutions against heat precipitation.
- Low concentrations of Ca-ions did not negatively affect chemical or biological stability.
- Unlike sugar additives, Ca-ions provided stabilization without compromising overall insulin quality.
Conclusions:
- Low concentrations of Ca-ions represent a viable and physiologically acceptable strategy for stabilizing neutral insulin solutions.
- This approach enhances physical stability crucial for insulin delivery devices.
- Ca-ion addition maintains essential chemical and biological quality parameters of insulin.