The significance of DNA-damage assays in toxicity and carcinogenicity assessment

Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).

Oncogene·2007

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Oncogene·2006

Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.

Journal of medicinal chemistry·2001

How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?

Cell biochemistry and biophysics·2001

Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors.

Annals of the New York Academy of Sciences·2001

Effects of c-erbB2 overexpression on the drug sensitivities of normal human mammary epithelial cells.

Journal of the National Cancer Institute·2000

Bidirectional Interaction Between Clock Genes and Reactive Oxygen Species Production in Carp and Zebrafish Macrophages.

Annals of the New York Academy of Sciences·2026

Enrichment of In Utero Rhythmic Experience Promotes Postnatal Visuospatial Attention.

Annals of the New York Academy of Sciences·2026

Hydrostatic Pressure-Mediated Chondrocyte Homeostasis in Osteoarthritis and Cartilage Engineering.

Annals of the New York Academy of Sciences·2026

Learning Spatially Adaptive Blur Representations for Stable Deconvolution in Electron Microscopy.

Annals of the New York Academy of Sciences·2026

PGNet: Progressive Feature Alignment and Gaussian Geometric-Consistency Assignment for Ship Detection in Complex Maritime Environments.

Annals of the New York Academy of Sciences·2026

Sustained High-Loneliness States in Persistent Depressive Disorder: An Ecological Momentary Assessment Study.

Annals of the New York Academy of Sciences·2026

Triple Genetic Alterations (EGFR Mutation, ALK Fusion, and MET Polysomy) in Gynecological Metastasis of Lung Adenocarcinoma Patient with Acquired Resistance to Furmonertinib: A Case Report.

Current oncology (Toronto, Ont.)·2026

Up-Front Immune Checkpoint Inhibitors in Patients with Multiple Synchronous Primary Tumors, Including dMMR/MSI-H Gastrointestinal Malignancies: A Case Series and Review of the Literature.

Current oncology (Toronto, Ont.)·2026

Advanced Therapies for Diabetic Kidney Disease: A Critical Review of Gene-, RNA-, and Cell-Based Strategies to Address Residual Risk.

Diseases (Basel, Switzerland)·2026

Association of DNA Copy Number Aberrations with Organ-Specific Metastasis in Luminal B HER2-Negative Breast Cancer.

Diseases (Basel, Switzerland)·2026

Carboxymethylcellulose/Hyaluronic Acid Hybrid Nanoconjugates: Toward Multifunctional Platforms for Melanoma Skin Cancer Theranostics.

Gels (Basel, Switzerland)·2026

Antagonistic TGR5 and FXR Signaling Shapes STAT1-Dependent Interferon Responses in Intestinal Epithelial Cells.

Cells·2026

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The significance of DNA-damage assays in toxicity and carcinogenicity assessment

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Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.

How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?

Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors.

Effects of c-erbB2 overexpression on the drug sensitivities of normal human mammary epithelial cells.

Bidirectional Interaction Between Clock Genes and Reactive Oxygen Species Production in Carp and Zebrafish Macrophages.

Enrichment of In Utero Rhythmic Experience Promotes Postnatal Visuospatial Attention.

Hydrostatic Pressure-Mediated Chondrocyte Homeostasis in Osteoarthritis and Cartilage Engineering.

Learning Spatially Adaptive Blur Representations for Stable Deconvolution in Electron Microscopy.

PGNet: Progressive Feature Alignment and Gaussian Geometric-Consistency Assignment for Ship Detection in Complex Maritime Environments.

Sustained High-Loneliness States in Persistent Depressive Disorder: An Ecological Momentary Assessment Study.

Triple Genetic Alterations (EGFR Mutation, ALK Fusion, and MET Polysomy) in Gynecological Metastasis of Lung Adenocarcinoma Patient with Acquired Resistance to Furmonertinib: A Case Report.

Up-Front Immune Checkpoint Inhibitors in Patients with Multiple Synchronous Primary Tumors, Including dMMR/MSI-H Gastrointestinal Malignancies: A Case Series and Review of the Literature.

Advanced Therapies for Diabetic Kidney Disease: A Critical Review of Gene-, RNA-, and Cell-Based Strategies to Address Residual Risk.

Association of DNA Copy Number Aberrations with Organ-Specific Metastasis in Luminal B HER2-Negative Breast Cancer.

Carboxymethylcellulose/Hyaluronic Acid Hybrid Nanoconjugates: Toward Multifunctional Platforms for Melanoma Skin Cancer Theranostics.

Antagonistic TGR5 and FXR Signaling Shapes STAT1-Dependent Interferon Responses in Intestinal Epithelial Cells.

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The significance of DNA-damage assays in toxicity and carcinogenicity assessment

Related Concept Videos

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