[Clinico-morphological characteristics of nonspecific reactive hepatitis]

Nonspecific reactive hepatitis is a manifestation or complication of various diseases, being a variety of secondary hepatitis. Its morphological characteristics are identical in all cases comprising hydropic and fatty degeneration of hepatocytes, their focal necroses in different parts of the lobules, predominantly macrophage and leukocyte infiltration of portal and intralobular stroma. Different morphological types of nonspecific reactive hepatitis are distinguished with regard to location of inflammatory lesions in different parts of the lobules and to their degree of activity. Morphological differential diagnosis of nonspecific reactive hepatitis from chronic hepatitis of viral, drug, and alcohol etiology is described. However, problems of morphogenesis, mechanism of development and differential diagnosis of this kind of chronic liver inflammation have not been studied sufficiently as yet.