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Cord blood macrophages present bacterial antigen (Escherichia coli) to paternal T cells

G J Zlabinger, J W Mannhalter, M M Eibl

    Clinical Immunology and Immunopathology
    |September 1, 1983
    PubMed

    Insights

    Newborn monocytes (cord-blood M phi s) effectively present antigens and stimulate T cells, demonstrating maturity at birth. These findings highlight the innate immune system

    Area of Science:

    • Immunology
    • Cell Biology
    • Neonatal Immunity

    Background:

    • Mononuclear phagocytes (M phi s) are crucial for immune responses.
    • The maturity of neonatal immune cells, particularly monocytes, is not fully understood.

    Purpose of the Study:

    • To investigate the functional maturity of human cord-blood monocytes (cord-blood M phi s).
    • To assess their capacity for antigen presentation and cytokine production.

    Main Methods:

    • Co-culturing cord-blood M phi s with antigen-pulsed Escherichia coli or tetanus toxoid.
    • Measuring T cell proliferation and interleukin-1 release.
    • Utilizing immunoadsorption to assess T cell removal.

    Main Results:

    • Cord-blood M phi s presented antigens and induced T cell proliferation comparably to adult M phi s.
    • They expressed surface Ia and released interleukin-1 upon stimulation.
    • Demonstrated the ability to remove antigen-specific T cells, indicating antigen expression.

    Conclusions:

    • Human mononuclear phagocytes are functionally mature at birth.
    • Cord-blood M phi s exhibit key characteristics of antigen-presenting cells.
    • Supports the concept of innate immune competence in newborns.

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