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Related Experiment Videos

Metoclopramide and breast milk.

H de Gezelle, W Ooghe, M Thiery

    European Journal of Obstetrics, Gynecology, and Reproductive Biology
    |April 1, 1983
    PubMed
    Summary

    Metoclopramide significantly increased milk yield by 50% in nursing mothers. This drug also accelerated the transition from colostrum to mature breast milk by altering amino acid composition.

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    Area of Science:

    • Obstetrics and Gynecology
    • Lactation Physiology
    • Pharmacology

    Background:

    • Metoclopramide is a dopamine antagonist with potential effects on prolactin and milk production.
    • Understanding the impact of pharmacological interventions on lactation is crucial for maternal and infant health.

    Purpose of the Study:

    • To evaluate the efficacy of metoclopramide in enhancing milk yield and accelerating milk composition changes in primiparous nursing mothers.
    • To assess the effects of metoclopramide on serum prolactin levels and breast milk composition.

    Main Methods:

    • A placebo-controlled, double-blind trial involving 13 primiparous nursing mothers.
    • Metoclopramide (10 mg, 3 times daily) or placebo administered from the first postpartum day for 8 days.
    • Measurements included serum prolactin, milk yield, and detailed breast milk composition analysis (including amino acids) over 3 weeks.

    Main Results:

    • Metoclopramide treatment resulted in approximately 50% greater total milk yield compared to the placebo group during the early puerperium.
    • Breast milk composition evolved similarly between groups, with the exception of amino acid content.
    • The shift in amino acid composition, indicative of the transition from colostrum to mature milk, occurred earlier in the metoclopramide-treated group.

    Conclusions:

    • Metoclopramide effectively increases milk yield in early postpartum nursing mothers.
    • Metoclopramide accelerates the maturation of breast milk composition, specifically influencing the amino acid profile.
    • These findings suggest metoclopramide as a potential therapeutic agent to support lactation in mothers experiencing low milk production.

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