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Related Experiment Videos

Immune complexes in normal subjects.

I J Simpson, M J Myles, G W Smith

    Journal of Clinical & Laboratory Immunology
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Normal immune complex (IC) levels show significant variation between assays and individuals. The sources of this variability in normal plasma remain unexplained, despite various testing methods.

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    Area of Science:

    • Immunology
    • Clinical Chemistry

    Background:

    • Immune complexes (IC) are crucial in immune responses but their levels in healthy individuals are not well-defined.
    • Understanding normal IC levels and their fluctuations is essential for interpreting abnormal findings in disease states.

    Purpose of the Study:

    • To investigate the variability of immune complex (IC) levels in healthy subjects using multiple established assays.
    • To identify factors that may influence IC levels in normal individuals.

    Main Methods:

    • Utilized four distinct assays: C1q solid phase, C1q deviation, C1q binding, and polyethylene glycol precipitation.
    • Measured IC levels in normal subjects under various conditions, including meals, time of day, exercise, and prednisone administration.

    Main Results:

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    • Significant variations in IC levels were observed across all assays in normal subjects.
    • No consistent patterns of variation were found between different assays, subjects, or even within the same subject over time.
    • Factors such as meals, time of day, exercise, and prednisone did not consistently alter IC levels.

    Conclusions:

    • Low levels of immune complexes are considered normal in plasma.
    • The significant day-to-day and inter-assay variability in normal IC levels is not readily explained by common physiological or external factors.
    • Normal immune complexes likely represent a heterogeneous mixture of specific and non-specific complexes, contributing to measurement variability.