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[Spinal concentrations of amoxicillin in purulent meningitis in children]
Insights
This study evaluated amoxicillin treatment for purulent meningitis in children. Amoxicillin achieved measurable levels in cerebrospinal fluid (CSF), indicating its potential efficacy in treating bacterial meningitis.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacokinetics
- Bacterial Meningitis
Context:
- Purulent meningitis poses a significant threat to children's health.
- Antibiotic penetration into the cerebrospinal fluid (CSF) is crucial for effective treatment.
- Amoxicillin is a widely used antibiotic for various bacterial infections.
Purpose:
- To assess the efficacy of amoxicillin in treating pediatric purulent meningitis.
- To determine amoxicillin concentrations in the CSF following intramuscular administration.
- To evaluate the CSF/serum ratio of amoxicillin during treatment.
Summary:
- A total of 115 children with purulent meningitis received amoxicillin (200 mg/kg/day) via intramuscular injections.
- CSF samples were collected at 1, 3, and 6 hours post-injection to measure amoxicillin levels.
- CSF amoxicillin levels were found to be 6.9-1.7-1.4 µg/ml in the first 48 hours and 4.4-1.7-1.9 µg/ml after one week.
- The CSF/serum concentration ratio ranged from 5% to 9.8% at the start of therapy.
Impact:
- Provides pharmacokinetic data on amoxicillin in pediatric CSF.
- Supports the use of amoxicillin for treating bacterial meningitis in children.
- Informs optimal dosing strategies for amoxicillin in pediatric meningitis cases.
Abstract:
Hundred and fifteen children suffering of purulent meningitis (S.pneumoniae: 19; H.influenzae: 44; N.meningitidis; 23; others: 29) were treated by amoxicillin 200 mg/kg/day in four intramuscular injections. Spinal taps for assay of antibiotic levels in the CSF were taken 1 or 3 or 6 hours after the injection. The levels were respectively for this samples of 6.9 -1.7-1.4 micrograms/ml during the first 48 hours of treatment and 4.4-1.7-1.9 after one week. The concentrations CSF/serum were from 5 to 9.8 per cent at the beginning of treatment.