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Related Experiment Videos

The tumor phenotype and the human gene map.

N K Honey, T B Shows

    Cancer Genetics and Cytogenetics
    |November 1, 1983
    PubMed
    Summary

    Tumor development involves genetic rearrangements and altered gene expression across the human genome. Understanding these complex genetic and metabolic changes, including oncogenes, is crucial for cancer research.

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    Cytogenetics and cell genetics·2000

    Area of Science:

    • Genetics
    • Oncology
    • Molecular Biology

    Background:

    • Tumorigenesis is characterized by genetic alterations and changes in gene product expression.
    • The human genome is extensively involved in the development of the tumor phenotype.
    • Tumor cells exhibit altered metabolic demands, leading to changes in enzyme and protein expression.

    Purpose of the Study:

    • To review genes associated with the tumor phenotype and their mapping on the human gene map.
    • To present nonrandom chromosomal aberrations frequently observed in tumors.
    • To describe altered gene expression patterns, including oncogenes, and their significance in cancer.

    Main Methods:

    • Review of existing literature on tumor genetics and gene mapping.
    • Compilation and presentation of data on chromosomal aberrations in tumors.
    • Analysis of altered gene expression patterns and metabolic changes in tumor cells.

    Main Results:

    • Genes associated with the tumor phenotype have been mapped on the human gene map, illustrating genome-wide involvement.
    • Frequently observed nonrandom chromosomal aberrations in tumors are presented.
    • Altered gene expression of enzymes and proteins reflects the metabolic demands of tumor cells, with oncogene assignments tabulated.

    Conclusions:

    • The tumor phenotype involves extensive genetic alterations across the human genome.
    • Chromosomal aberrations and altered gene expression are key features of tumors.
    • Understanding the complex interplay of genetic and metabolic changes is vital for advancing our knowledge of tumor origins and development.

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